![]() But growing use of genetic testing that analyzes single-nucleotide polymorphisms (SNPs, pronounced "snips"), which are variations in single building blocks of DNA, can inadvertently reveal the secrets of a child's birth. In 40 years of doing clinical genetics, Beaudet said he occasionally saw a child whose mother and father were close relatives. Like most areas of medicine, it really depends on the circumstances of the case before you." That's what makes it difficult to develop general, definitive practice guidelines. "If there's multiple first-degree relatives, you wouldn't be able to discern whether it was dad, or a brother. McGuire, an attorney who is an associate professor of medicine at Baylor's Center for Medical Ethics and Health Policy, said that as soon as geneticists learned that incest appeared to be an issue for some of their young patients, a committee of ethicists, geneticists and attorneys began "to think through the issues, looking at the laws and some of the ethical considerations related to this and coming up with a policy that the hospitals can use to manage these cases when they come up."Įven with genetic evidence that a child's mother and father are biologically related, "you can't tell from the test definitively who the biological father is," McGuire said. ![]() They suggested that the American College of Medical Genetics, American Society of Human Genetics and European Society of Human Genetics draft practice guidelines addressing consent, disclosure and reporting.Īmy L. Such revelations could cause harm "in the form of stigmatization, emotional distress and criminal accusations," Beaudet and his co-authors wrote in the correspondence appearing in the journal. Revelations About Heredity Could Create Stigma, Distress and More "But now we see a child where we don't suspect that, and the lab result comes back and says … this child is the product of mating between two very closely related individuals." "It used to be in the past that occasionally we would be suspicious, or occasionally a child would be brought in, and social services would be involved and tell us," about incestuous parentage, said Beaudet, a pediatrician also trained in genetics. No one has good estimates on the prevalence of children born from incestuous relationships. "Although such revelations might provide important diagnostic clues to the underlying disorders, they also raise important legal and ethical concerns," Beaudet and colleagues wrote in the current issue of The Lancet.Ĭhildren of first-degree relatives face a risk of disability up to 50 percent higher than that of children born to unrelated moms and dads, Beaudet said. However, wider use of such testing in children with disabilities is expected to identify additional cases of incestuous parentage. Beaudet, chairman of Baylor's department of molecular and human genetics. In the few months that Baylor has been performing these detailed genetic tests, there have been fewer than 10 cases of consanguinity - the phenomenon of inheriting the same gene variations from two closely related people, said Dr. Had the mothers and fathers of these youngsters been unrelated, those same stretches of DNA would have differed. Children who inherited half as much identical DNA from both parents likely were the offspring of second-degree relatives, such as an uncle and niece. That suggested their parents were first-degree relatives - father and daughter, brother and sister, or mother and son. 10, 2011— - The genetic tests that have revolutionized the identification and treatment of many illnesses can also unearth family secrets like incest, sparking an ethical discussion in the medical community over how these inadvertent findings should be handled.Īt Baylor College of Medicine in Houston, sophisticated DNA analyses used to diagnose such disabilities as birth defects, epilepsy or developmental delays revealed that in some children, about 25 percent of genetic material inherited from their mother was the same as material inherited from their father.
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